The bottom line
Pooled trials point to modest short-term improvements in knee osteoarthritis pain and in functional dyspepsia symptoms, but the trials are mostly small and use many different extracts[7, 8, 11]. Findings for depression, blood sugar, fatty liver and ulcerative colitis are mixed or low-certainty, and a trial in Alzheimer's disease found no effect[9, 13, 14, 15, 16]. NCCIH says there is not enough evidence to conclude that turmeric or curcumin is beneficial for any health purpose, and the EMA found the data insufficient for a 'well-established use' indication[2, 5].
meta-analysisEvidence: moderate
Knee osteoarthritis (pooled)
15 RCTs, 1,621 participants; Curcuma longa extract or curcumin vs placebo or NSAIDs
Compared with placebo, turmeric extract and curcumin were associated with lower pain (VAS and WOMAC pain) and better WOMAC function and stiffness scores, with adverse events similar to placebo. Compared with NSAIDs, effects on pain, function and stiffness were similar and adverse events were fewer.[7, 2, 28]
Limitations: Trials used many different extracts, doses and durations. NCCIH describes the evidence for osteoarthritis as positive but initial, and says higher-quality evidence is needed.
RCTEvidence: limited
Knee osteoarthritis
n=70 adults with knee osteoarthritis and effusion-synovitis on ultrasound; 12 weeks; 2 capsules/day of Curcuma longa extract vs placebo; single centre, Tasmania
Knee pain on a visual analogue scale improved by 9.1 mm more than with placebo (95% CI -17.8 to -0.4), and WOMAC knee pain also improved. The extract did not change effusion-synovitis volume on MRI or cartilage composition. Adverse events were similar between groups.[8, 28]
Limitations: Modest sample and short duration, as the authors note; part-funded by the extract's manufacturer. The authors call for larger multicentre trials to judge clinical significance.
systematic reviewEvidence: moderate
Functional dyspepsia (pooled)
Cochrane review of 41 trials of 27 non-Chinese herbal medicines; Curcuma longa vs placebo in 2 studies (110 participants)
Curcuma longa probably results in a moderate improvement in global dyspepsia symptoms at four weeks versus placebo (MD -3.33, 95% CI -5.84 to -0.81; moderate-certainty evidence), with probably little or no difference in adverse events. Against other active treatments it may give little or no added benefit.[11]
Limitations: Only two small placebo-controlled studies; the review calls for more high-quality trials.
RCTEvidence: limited
Functional dyspepsia
n=132 adults with Rome IV functional dyspepsia; 4 weeks; curcumin vs omeprazole vs placebo; double-blind, Thailand
Pain and non-pain symptom scores fell more with curcumin than with placebo, and did not differ significantly from omeprazole.[10, 4]
Limitations: Single centre and short follow-up. The European Union's traditional-use monograph also lists relief of digestive disturbances (fullness, slow digestion, flatulence), but on the basis of long-standing use rather than trial evidence.
meta-analysisEvidence: limited
Depression and depressive symptoms (pooled)
10 trials, 594 patients; curcumin vs placebo or as add-on
Curcumin was associated with a small reduction in depressive symptoms (SMD -0.32, 95% CI -0.50 to -0.13) and higher response rates, with drop-outs and side effects similar to control.[9]
Limitations: The authors rated the evidence as low quality and say there is great uncertainty about efficacy and acceptability. In the subgroup with depressive symptoms (rather than diagnosed depression) there was no significant effect.
meta-analysisEvidence: limited
Blood sugar in prediabetes and type 2 diabetes (pooled)
34 RCTs (39 treatment arms); curcumin or turmeric vs control; searches to August 2025
Supplementation was associated with lower fasting glucose (about -10 mg/dL), HbA1c (-0.32 percentage points) and insulin resistance (HOMA-IR) than control. Effects appeared larger at doses of 1 g/day or more and varied by formulation.[14]
Limitations: Significant heterogeneity across trials; the authors say caution is needed and that high-quality RCTs are still required.
meta-analysisEvidence: limited
Fatty liver disease (NAFLD) liver enzymes
15 RCTs, 835 participants with NAFLD; curcumin vs control
Curcumin did not change ALT but did lower AST. Adding piperine gave no benefit. Longer trials and higher relative doses were associated with smaller enzyme reductions.[15, 2]
Limitations: High heterogeneity. NCCIH notes that it is unclear which NAFLD measures are consistently improved.
meta-analysisEvidence: preliminary
Ulcerative colitis, add-on to standard therapy (mixed results)
Two meta-analyses of small RCTs: 3 RCTs analysed (2018) and 6 RCTs, 385 participants (2022)
The 2018 analysis found that, using the more accurate statistical model, oral curcumin was not superior to placebo for attaining remission. The 2022 analysis found more clinical remission with add-on curcumin (RR 2.10, 95% CI 1.13 to 3.89) but no significant difference in clinical improvement or endoscopic remission.[12, 13]
Limitations: Very few, small trials with differing doses and formulations; the conclusions of the two reviews differ.
RCTEvidence: limited
Alzheimer's disease (null result)
n=36 with mild-to-moderate Alzheimer's disease; 24 weeks; curcumin 2 g/day or 4 g/day vs placebo
There were no differences between groups in clinical or biomarker measures. Plasma levels of native curcumin were low, and 3 of 24 curcumin-treated participants withdrew because of gastrointestinal symptoms.[16, 28]
Limitations: Small pilot trial. The authors suggest limited bioavailability may explain the lack of effect.